Archive for outubro 29th, 2016

Limpeza doas Janelas abertas – 10/29/2016

sábado, outubro 29th, 2016

xxxx

Jack Szostak: Reconstructing the First Cells

https://www.youtube.com/watch?v=jmMU0b20FSg&list=PLrkvqYtQI86BdmETUlItRNyW0GDocutuw&index=2

xxxx

Google search

Daniel G. Gibson, et al. 2010. Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome. Science 329:52–56

xxxx

The proteomic complexity and rise of the primordial ancestor of diversified life

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123224/

xxxx

Google search

CREATION OF A BACTERIAL CELL CONTROLLED BY A CHEMICALLY SYNTHESIZED GENOME

xxxx

1st Cell with Synthetic Genome

http://www.the-scientist.com/?articles.view/articleNo/29039/title/1st-cell-with-synthetic-genome/

xxxx

O link para o pdf abaixo veio de:

http://www.nature.com/nature/journal/v465/n7297/pdf/465422a.pdf

Life after the synthetic cell (pdf)

http://www.nature.com/articles/465422a.epdf?referrer_access_token=Sg8m2YG3KRENKu1YALNNbNRgN0jAjWel9jnR3ZoTv0PQ4M7lEKZ1QECIyVPCzvJxKAQvsc2dNPyWEgOe8RiMKSWd6bPR5cUibBHsygPOjELADAxdE3ELd6sO7iz_6mrkQYevMTaolSx0vIQEWxc38AjybPCJxcc6-LebqUiTBra1bGQ5SgCTmKgzKAt4AxjPU0Na_SwSaX3MOv0eTL8eAs5sL677lEniquDLqL1uZDPvavgBehOuhZ9PDUOnJNOazs_cBEAbVhJs5EyEiriEgw%3D%3D&tracking_referrer=www.the-scientist.com

xxxxx

 

Origem do Primordial Ancestral (LUCA) da Vida Diversificada e a Complexidade do Proteoma

sábado, outubro 29th, 2016

xxxx

The proteomic complexity and rise of the primordial ancestor of diversified life

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123224/

Published online 2011 May 25. doi:  10.1186/1471-2148-11-140

( Ler o artigo, depois traduzi-lo)

Background

The last universal common ancestor represents the primordial cellular organism from which diversified life was derived.

O ultimo universal comum ancestral representa o organismo celular primordial a partir do qual a diversificação da vida foi derivada.

Evolução do Proteoma e Origem Metabólica da Transcrição e da Vida Celular

sábado, outubro 29th, 2016

xxxx

(Este artigo não tenho acesso. Copiado aqui o endereço e abstrato para traduzir)

Proteome Evolution and the Metabolic Origins of Translation and Cellular Life

http://link.springer.com/article/10.1007/s00239-010-9400-9

Article:

Abstract

The origin of life has puzzled molecular scientists for over half a century. Yet fundamental questions remain unanswered, including which came first, the metabolic machinery or the encoding nucleic acids. In this study we take a protein-centric view and explore the ancestral origins of proteins. Protein domain structures in proteomes are highly conserved and embody molecular functions and interactions that are needed for cellular and organismal processes. Here we use domain structure to study the evolution of molecular function in the protein world. Timelines describing the age and function of protein domains at fold, fold superfamily, and fold family levels of structural complexity were derived from a structural phylogenomic census in hundreds of fully sequenced genomes. These timelines unfold congruent hourglass patterns in rates of appearance of domain structures and functions, functional diversity, and hierarchical complexity, and revealed a gradual build up of protein repertoires associated with metabolism, translation and DNA, in that order. The most ancient domain architectures were hydrolase enzymes and the first translation domains had catalytic functions for the aminoacylation and the molecular switch-driven transport of RNA. Remarkably, the most ancient domains had metabolic roles, did not interact with RNA, and preceded the gradual build-up of translation. In fact, the first translation domains had also a metabolic origin and were only later followed by specialized translation machinery. Our results explain how the generation of structure in the protein world and the concurrent crystallization of translation and diversified cellular life created further opportunities for proteomic diversification.