Cérebro e Diabetes, Novos Circuitos para Matrix/DNA Pesquisar

Brain may play key role in blood sugar metabolism and diabetes development

http://www.washington.edu/news/2013/11/06/brain-may-play-key-role-in-blood-sugar-metabolism-and-diabetes-development/

UW Health Sciences and UW Medicine – November 6, 2013

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A growing body of evidence suggests that the brain plays a key role in glucose regulation and the development of type 2 diabetes, researchers write in the Nov. 7 ssue of the journal Nature. If the hypothesis is correct, it may open the door to entirely new ways to prevent and treat this disease, which is projected to affect one in three adults in the United States by 2050.

the brain was originally thought to play an important role in maintaining normal glucose metabolism 

Pesquisa:

glucose metabolism

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With the discovery of insulin in the 1920s, the focus of research and diabetes care shifted to almost exclusively to insulin. Today, almost all treatments for diabetes seek to either increase insulin levels or increase the body’s sensitivity to insulin.

Pesquisa:

insulin

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“These drugs,” the researchers write, “enjoy wide use and are effective in controlling hyperglycemia [high blood sugar levels], the hallmark of type 2 diabetes, but they address the consequence of diabetes more than the underlying causes, and thus control rather than cure the disease.”

New research, they write, suggests that normal glucose regulation depends on a partnership between the insulin-producing cells of the pancreas, the pancreatic islet cells, and neuronal circuits in the hypothalamus and other brain areas that are intimately involved in maintaining normal glucose levels.

Pesquisa:

insulin-producing cells of the pâncreas

 the pancreatic islet cells

neuronal circuits in the hypothalamus

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One such mechanism by which the system promotes glucose uptake by tissues is by stimulating what is called “glucose effectiveness.” As this process accounts for almost 50 percent of normal glucose uptake, it rivals the impact of insulin-dependent mechanisms driven by the islet cells in the pancreas.

The development of type 2 diabetes appears to involve the failure of both systems, the researchers say. Impairment of the brain-centered system is common, and it places an increased burden on the islet-centered system. For a time, the islet-centered system can compensate, but if it begins to fail, the brain-centered system may decompensate further, causing a vicious cycle that ends in diabetes.

Boosting insulin levels alone will lower glucose levels, but only addresses half the problem. To restore normal glucose regulation requires addressing the failures of the brain-centered system as well. Approaches that target both systems may not only achieve better blood glucose control, but could actually cause diabetes to go into remission, they write.

Comentário:

Portanto isto é questão de equilíbrio de um inteiro sistema, e isto envolve comparações com a formula da Matrix/DNA

In addition to Schwartz, the authors of the Nature paper “Cooperation between brain and islet in glucose homeostasis and diabetes

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