DNA:Aceita ou não uma mutação para melhor?
Registrado para retornar a ler:
Journal Molecular Evolution
DOI 10.1007/s00239-010-9408-1
http://www.springerlink.com/content/b628621138157551/fulltext.pdf
Evolution of Prokaryotic Genes by Shift of Stop Codons
Anna A. Vakhrusheva • Marat D. Kazanov •
Andrey A. Mironov • Georgii A. Bazykin
Received: 28 July 2010 / Accepted: 29 October 2010
Springer Science+Business Media, LLC 2010
Introduction
Although most new genes originate by duplication of preexisting
genes (Ohno
1970; Lynch and Conery 2000; Lynch2007
have also evolved out of non-coding sequences (Cai et al.
; Vitreschak et al. 2008), new protein-coding genes2008
are rare, because immediate functionality of a long previously
non-functional sequence is rarely easily achievable,
and translation of a long segment of such sequence is nearly
certain to be deleterious.
Conversely, recruitment of short regions of DNA for
fulfillment of various functions is wide-spread. This is
probably because shorter novel functional regions are more
likely to be immediately adaptive, or at least not too deleterious.
For example, non-functional DNA readily evolves
into short regulatory sequences
; Zhou et al. 2008; Li et al. 2010). However, such cases
