Posts Tagged ‘proteins’

Circadian Rythym: the big puzzle…

Sunday, January 5th, 2020

Without an alarm or other external source for waking us up, what prevents our brains from being asleep forever?

The scientific explanation: You have a really complicated internal clock called your circadian rythym that helps you know when to sleep and wake up. In short you have neurons that run in a loop, activating and deactivating themselves (a bit like a Redstone clock actually if you play minecraft), and similar proteins too that inhibit their own production so they come in waves. Essentially, using these complicated systems and synchronizing them frequently with light and other stimuli, your body can determine when to sleep, when to wake up, how to regulate temperature, and so on. This system would wake us up after about eight hours of sleep by stopping melatonin, and increasing seratonin, dopamine, acetylcholine, and norepinephrine production. Without the external cues though our body has a tendency to drift from 24 sleep cycles to slightly longer cycles (anywhere from 15 minutes to several hours longer, depending on the study.)

What are these self-inhibiting proteins and how does this work? It’s actually called CLOCK (I know, biologists are great at naming things. Stands for Circadian Locomotor Output Cycles Kaput) and it can bind to its own section of the DNA and prevent it from being transcribed. So as more of it is made, the higher the chance it is bound more often and less of it is produced, then as it degrades over time it begins to be produced more and more again, restarting the cycle.

The Matrix/DNA comments: Self-inhibiting proteins and self-activated or self-deactivated neurons?! Ok if you believe in it. I am sure it is not a proved scientific fact. How it could be? Any kind of “self” implies a command coming from inside. Proteins and neurons are merely a bunch of atoms. There are no self-rolling stones. I think the problem here is the conflict between reductionist/systemic mindset. It is an opened question waiting for work by opened minds. At Matrix/DNA world view we believe that all these movements are result of the flow of information/energy that runs inside a circuit of a dynamic formula which can be designed as a simple diagram software. It happens that we are detecting this formula every time we see a new natural system. This formula is the software behind a fundamental unit of information of DNA ( two lateral opposite nucleotides), it is the template of brain anatomy, as well the template of any building blocks of astronomic systems. So, the circadian rythym in a human body is produced at same time by the bigger astronomic fractal as the smaller genetic DNA fractal totally synchronized. The formula is the master, neurons and proteins are the soldiers. Soldiers at work are not self-something. But, like the reductionist can not show the internal trigger of selfies in neurons and proteins, we can not show also the internal and external formula, which must be composite by a network of photons.

SirWallaceIIofReddit – answering to Matrix/DNA comments:

They are definetely real, like just finished reading about them in my text books real. The proteins work like I described in my other comment, inhibiting the DNA that codes for them, but I did oversimplify the neurons thing. They are actually cirquits of neurons. The super simplified version would be a two neuron systems. One of them is inhibitory and one excitatory, and both send signals to the other. The excitatory one activates, activating the inhibitory one, which deactivated the excitatory one, which stops activating the inhibitory one, and so on and so forth, creating a reliable rhythm. As for the second half of your post I’m a little confused, could you try to explain it a different way?

MatrixDNA answering to SirWallace:

I agree with your description about what we see, our disagrement is about the explanation and the primary causes. I think that it would be good for you trying to look at a new perspective of the brain – which is at my website ( I don’t want divulgation here but there is no other way). It has a lot of food for thought and new discoveries. The brain is itself a natural system and all natural systems are build by a unique natural formula, which is at my website. Then, if you superpose the brain’s anatomy upon the formula, you can see the systemic circuit flowing and activating glandules, neurons, proteins, etc. The hippocampus is upon F1 and the cortex is upon F4. Pay attention that the formula is divided into two halves. The left side is energy up, the right side begins entropy, so, is energy down. So, a neuron is not inhibitory or excitatory by itself, it is the systemic flow that control them; if the flow is up, the neuron is activated while the other os kept entropically null. When a protein ( or the code for it) meets its counterpart of the other half, both are out. I know that you will not understand it now, it is not a complex issue, but it is different from everything we have learned. In theory, it has worked very well for me… Cheers…

https://www.reddit.com/r/askscience/comments/ejsa6q/without_an_alarm_or_other_external_source_for/