DNA:Aceita ou não uma mutação para melhor?

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Journal Molecular Evolution
DOI 10.1007/s00239-010-9408-1


Evolution of Prokaryotic Genes by Shift of Stop Codons
Anna A. Vakhrusheva • Marat D. Kazanov •
Andrey A. Mironov • Georgii A. Bazykin
Received: 28 July 2010 / Accepted: 29 October 2010
 Springer Science+Business Media, LLC 2010




Although most new genes originate by duplication of preexisting

genes (Ohno

1970; Lynch and Conery 2000; Lynch2007

have also evolved out of non-coding sequences (Cai et al.

; Vitreschak et al. 2008), new protein-coding genes2008

are rare, because immediate functionality of a long previously

non-functional sequence is rarely easily achievable,

and translation of a long segment of such sequence is nearly

certain to be deleterious.

Conversely, recruitment of short regions of DNA for

fulfillment of various functions is wide-spread. This is

probably because shorter novel functional regions are more

likely to be immediately adaptive, or at least not too deleterious.

For example, non-functional DNA readily evolves

into short regulatory sequences

; Zhou et al. 2008; Li et al. 2010). However, such cases

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